Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

PPARγ has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds and activates PPARγ by acting as a modulator. Activation of PPARγ by apigenin blocks p65 translocation into nuclei through inhibition of p65...

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Bibliographic Details
Main Authors: Feng, Xiujing, Weng, Dan, Zhou, Feifei, Owen, Young D., Qin, Haohan, Zhao, Jingfa, WenYu, Huang, Yahong, Chen, Jiajia, Fu, Haijian, Yang, Nanfei, Chen, Dianhua, Li, Jianxin, Tan, Renxiang, Shen, Pingping
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972579/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972579/

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