Pituitary response to thyrotropin releasing hormone in children with overweight and obesity

Pituitary response to thyrotropin releasing hormone in children with overweight and obesity

Thyroid stimulating hormone (TSH) concentrations in the high normal range are common in children with overweight and obesity, and associated with increased cardiovascular disease risk. Prior studies aiming at unravelling the mechanisms underlying these high TSH concentrations mainly focused on facto...

Full description

Bibliographic Details
Main Authors: Rijks, Jesse, Penders, Bas, Dorenbos, Elke, Straetemans, Saartje, Gerver, Willem-Jan, Vreugdenhil, Anita
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971570/
id pubmed-4971570
recordtype oai_dc
spelling pubmed-49715702016-08-11 Pituitary response to thyrotropin releasing hormone in children with overweight and obesity Rijks, Jesse Penders, Bas Dorenbos, Elke Straetemans, Saartje Gerver, Willem-Jan Vreugdenhil, Anita Article Thyroid stimulating hormone (TSH) concentrations in the high normal range are common in children with overweight and obesity, and associated with increased cardiovascular disease risk. Prior studies aiming at unravelling the mechanisms underlying these high TSH concentrations mainly focused on factors promoting thyrotropin releasing hormone (TRH) production as a cause for high TSH concentrations. However, it is unknown whether TSH release of the pituitary in response to TRH is affected in children with overweight and obesity. Here we describe TSH release of the pituitary in response to exogenous TRH in 73 euthyroid children (39% males) with overweight or (morbid) obesity. Baseline TSH concentrations (0.9–5.5 mU/L) were not associated with BMI z score, whereas these concentrations were positively associated with TSH concentrations 20 minutes after TRH administration (r2 = 0.484, p < 0.001) and the TSH incremental area under the curve during the TRH stimulation test (r2 = 0.307, p < 0.001). These results suggest that pituitary TSH release in response to TRH stimulation might be an important factor contributing to high normal serum TSH concentrations, which is a regular finding in children with overweight and obesity. The clinical significance and the intermediate factors contributing to pituitary TSH release need to be elucidated in future studies. Nature Publishing Group 2016-08-03 /pmc/articles/PMC4971570/ /pubmed/27485208 http://dx.doi.org/10.1038/srep31032 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Rijks, Jesse
Penders, Bas
Dorenbos, Elke
Straetemans, Saartje
Gerver, Willem-Jan
Vreugdenhil, Anita
spellingShingle Rijks, Jesse
Penders, Bas
Dorenbos, Elke
Straetemans, Saartje
Gerver, Willem-Jan
Vreugdenhil, Anita
Pituitary response to thyrotropin releasing hormone in children with overweight and obesity
author_facet Rijks, Jesse
Penders, Bas
Dorenbos, Elke
Straetemans, Saartje
Gerver, Willem-Jan
Vreugdenhil, Anita
author_sort Rijks, Jesse
title Pituitary response to thyrotropin releasing hormone in children with overweight and obesity
title_short Pituitary response to thyrotropin releasing hormone in children with overweight and obesity
title_full Pituitary response to thyrotropin releasing hormone in children with overweight and obesity
title_fullStr Pituitary response to thyrotropin releasing hormone in children with overweight and obesity
title_full_unstemmed Pituitary response to thyrotropin releasing hormone in children with overweight and obesity
title_sort pituitary response to thyrotropin releasing hormone in children with overweight and obesity
description Thyroid stimulating hormone (TSH) concentrations in the high normal range are common in children with overweight and obesity, and associated with increased cardiovascular disease risk. Prior studies aiming at unravelling the mechanisms underlying these high TSH concentrations mainly focused on factors promoting thyrotropin releasing hormone (TRH) production as a cause for high TSH concentrations. However, it is unknown whether TSH release of the pituitary in response to TRH is affected in children with overweight and obesity. Here we describe TSH release of the pituitary in response to exogenous TRH in 73 euthyroid children (39% males) with overweight or (morbid) obesity. Baseline TSH concentrations (0.9–5.5 mU/L) were not associated with BMI z score, whereas these concentrations were positively associated with TSH concentrations 20 minutes after TRH administration (r2 = 0.484, p < 0.001) and the TSH incremental area under the curve during the TRH stimulation test (r2 = 0.307, p < 0.001). These results suggest that pituitary TSH release in response to TRH stimulation might be an important factor contributing to high normal serum TSH concentrations, which is a regular finding in children with overweight and obesity. The clinical significance and the intermediate factors contributing to pituitary TSH release need to be elucidated in future studies.
publisher Nature Publishing Group
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971570/
_version_ 1613620378103447552

Similar Items