Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection

The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription. We hence hypothesized that Vpr might be a determinant of non-activated T-cell infection....

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Bibliographic Details
Main Authors: Höhne, Kristin, Businger, Ramona, van Nuffel, Anouk, Bolduan, Sebastian, Koppensteiner, Herwig, Baeyens, Ann, Vermeire, Jolien, Malatinkova, Eva, Verhasselt, Bruno, Schindler, Michael
Format: Online
Language:English
Published: The Royal Society 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967821/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967821/

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