Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes
These occupational cholangiocarcinoma cases shared a high mutation burden, strand bias and unique trinucleotide mutational signatures, suggesting that the patients might have been exposed to a common strong mutagen. The underlying mechanisms of mutagenesis should be further investigated.
Bibliographic Details
| Main Authors: |
Mimaki, Sachiyo,
Totsuka, Yukari,
Suzuki, Yutaka,
Nakai, Chikako,
Goto, Masanori,
Kojima, Motohiro,
Arakawa, Hirofumi,
Takemura, Shigekazu,
Tanaka, Shogo,
Marubashi, Shigeru,
Kinoshita, Masahiko,
Matsuda, Tomonari,
Shibata, Tatsuhiro,
Nakagama, Hitoshi,
Ochiai, Atsushi,
Kubo, Shoji,
Nakamori, Shoji,
Esumi, Hiroyasu,
Tsuchihara, Katsuya |
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| Format: | Online
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| Language: | English |
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| Published: |
Oxford University Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967217/
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