Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes
These occupational cholangiocarcinoma cases shared a high mutation burden, strand bias and unique trinucleotide mutational signatures, suggesting that the patients might have been exposed to a common strong mutagen. The underlying mechanisms of mutagenesis should be further investigated.
Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
Oxford University Press
2016
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967217/ |