Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

These occupational cholangiocarcinoma cases shared a high mutation burden, strand bias and unique trinucleotide mutational signatures, suggesting that the patients might have been exposed to a common strong mutagen. The underlying mechanisms of mutagenesis should be further investigated.

Bibliographic Details
Main Authors: Mimaki, Sachiyo, Totsuka, Yukari, Suzuki, Yutaka, Nakai, Chikako, Goto, Masanori, Kojima, Motohiro, Arakawa, Hirofumi, Takemura, Shigekazu, Tanaka, Shogo, Marubashi, Shigeru, Kinoshita, Masahiko, Matsuda, Tomonari, Shibata, Tatsuhiro, Nakagama, Hitoshi, Ochiai, Atsushi, Kubo, Shoji, Nakamori, Shoji, Esumi, Hiroyasu, Tsuchihara, Katsuya
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967217/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967217/

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