Structure-guided development of heterodimer-selective GPCR ligands

Structure-guided development of heterodimer-selective GPCR ligands

Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for dopamine D2 receptor/neurotensin NTS1 receptor (D...

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Bibliographic Details
Main Authors: Hübner, Harald, Schellhorn, Tamara, Gienger, Marie, Schaab, Carolin, Kaindl, Jonas, Leeb, Laurin, Clark, Timothy, Möller, Dorothee, Gmeiner, Peter
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963535/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963535/

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