Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases

Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases

We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe−/−xTfr2mut mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family...

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Bibliographic Details
Main Authors: Heidari, Moones, Gerami, Sam H., Bassett, Brianna, Graham, Ross M., Chua, Anita C.G., Aryal, Ritambhara, House, Michael J., Collingwood, Joanna F., Bettencourt, Conceição, Houlden, Henry, Ryten, Mina, Olynyk, John K., Trinder, Debbie, Johnstone, Daniel M., Milward, Elizabeth A.
Format: Online
Language:English
Published: Taylor & Francis 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961263/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961263/

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