Control of the Inflammatory Macrophage Transcriptional Signature by miR-155

Inflammatory M1 spectrum macrophages protect from infection but can cause inflammatory disease and tissue damage, whereas alternatively activated/M2 spectrum macrophages reduce inflammation and promote tissue repair. Modulation of macrophage phenotype may be therapeutically beneficial and requires f...

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Bibliographic Details
Main Authors: Jablonski, Kyle A., Gaudet, Andrew D., Amici, Stephanie A., Popovich, Phillip G., Guerau-de-Arellano, Mireia
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957803/