DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Mutations in the epigenetic modifiers DNMT3A and TET2 non-randomly co-occur in lymphoma and leukemia despite their epistasis in the methylation-hydroxymethylation pathway. Using Dnmt3a and Tet2 double knock-out (DKO) mice in which malignancy development is accelerated, we show that the DKO methylome...

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Bibliographic Details
Main Authors: Zhang, Xiaotian, Su, Jianzhong, Jeong, Mira, Ko, Myunggon, Huang, Yun, Park, Hyun Jung, Guzman, Anna, Lei, Yong, Huang, Yung-Hsin, Rao, Anjana, Li, Wei, Goodell, Margaret A.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957136/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957136/

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