Acute loss of TET function results in aggressive myeloid cancer in mice

Acute loss of TET function results in aggressive myeloid cancer in mice

TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the r...

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Bibliographic Details
Main Authors: An, Jungeun, González-Avalos, Edahí, Chawla, Ashu, Jeong, Mira, López-Moyado, Isaac F., Li, Wei, Goodell, Margaret A., Chavez, Lukas, Ko, Myunggon, Rao, Anjana
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674670/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674670/

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