Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2‐microglobulin

Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2‐microglobulin

The first genetic variant of β2‐microglobulin (b2M) associated with a familial form of systemic amyloidosis has been recently described. The mutated protein, carrying a substitution of Asp at position 76 with an Asn (D76N b2M), exhibits a strongly enhanced amyloidogenic tendency to aggregate with re...

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Bibliographic Details
Main Authors: Leri, Manuela, Bemporad, Francesco, Oropesa‐Nuñez, Reinier, Canale, Claudio, Calamai, Martino, Nosi, Daniele, Ramazzotti, Matteo, Giorgetti, Sofia, Pavone, Francesco S., Bellotti, Vittorio, Stefani, Massimo, Bucciantini, Monica
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956941/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956941/

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