Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy

Inclusion of Strep-Tag II in design of antigen receptors for T cell immunotherapy

The tactical introduction of Strep-tag II into synthetic antigen receptors provides engineered T cells with a marker for identification and rapid purification, and a functional element for selective antibody coated microbead-driven large-scale expansion. Such receptor designs can be applied to chime...

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Bibliographic Details
Main Authors: Liu, Lingfeng, Sommermeyer, Daniel, Cabanov, Alexandra, Kosasih, Paula, Hill, Tyler, Riddell, Stanley R
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940167/
Description
Summary:The tactical introduction of Strep-tag II into synthetic antigen receptors provides engineered T cells with a marker for identification and rapid purification, and a functional element for selective antibody coated microbead-driven large-scale expansion. Such receptor designs can be applied to chimeric antigen receptors of different ligand specificities and costimulatory domains, and to T cell receptors to facilitate cGMP manufacturing of adoptive T cell therapies to treat cancer and other diseases.

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