UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans
Notch-type signaling mediates cell−cell interactions important for animal development. In humans, reduced or inappropriate Notch signaling activity is associated with various developmental defects and disease states, including cancers. Caenorhabditis elegans expresses two Notch-type receptors, GLP-1...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Genetics Society of America
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938665/ |