Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

Parkin is a RING-between-RING E3 ligase that functions in the covalent attachment of ubiquitin to specific substrates, and mutations in Parkin are linked to Parkinson’s disease, cancer and mycobacterial infection. The RING-between-RING family of E3 ligases are suggested to function with a canonical...

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Bibliographic Details
Main Authors: Riley, B.E., Lougheed, J.C., Callaway, K., Velasquez, M., Brecht, E., Nguyen, L., Shaler, T., Walker, D., Yang, Y., Regnstrom, K., Diep, L., Zhang, Z., Chiou, S., Bova, M., Artis, D.R., Yao, N., Baker, J., Yednock, T., Johnston, J.A.
Format: Online
Language:English
Published: Nature Pub. Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709503/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709503/

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