Molecular design and downstream processing of turoctocog alfa (NovoEight), a B-domain truncated factor VIII molecule

Molecular design and downstream processing of turoctocog alfa (NovoEight), a B-domain truncated factor VIII molecule

Turoctocog alfa (NovoEight) is a third-generation recombinant factor VIII (rFVIII) with a truncated B-domain that is manufactured in Chinese hamster ovary cells. No human or animal-derived materials are used in the process. The aim of this study is to describe the molecular design and purification p...

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Bibliographic Details
Main Authors: Ahmadian, Haleh, Hansen, Ernst B., Faber, Johan H., Sejergaard, Lars, Karlsson, Johan, Bolt, Gert, Hansen, Jens J., Thim, Lars
Format: Online
Language:English
Published: Lippincott Williams And Wilkins 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935534/

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