Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes
Drosophila Myt1 is essential for male fertility. Loss of Myt1 activity causes defective fusomes and premature centriole disengagement during premeiotic G2 phase due to lack of Myt1 inhibition of Cyclin A/Cdk1. These functions are distinct from known roles for Myt1 inhibition of Cyclin B/Cdk1 used to...
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| Format: | Online |
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The American Society for Cell Biology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927279/ |
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pubmed-49272792016-09-16 Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes Varadarajan, Ramya Ayeni, Joseph Jin, Zhigang Homola, Ellen Campbell, Shelagh D. Articles Drosophila Myt1 is essential for male fertility. Loss of Myt1 activity causes defective fusomes and premature centriole disengagement during premeiotic G2 phase due to lack of Myt1 inhibition of Cyclin A/Cdk1. These functions are distinct from known roles for Myt1 inhibition of Cyclin B/Cdk1 used to regulate G2/MI timing. The American Society for Cell Biology 2016-07-01 /pmc/articles/PMC4927279/ /pubmed/27170181 http://dx.doi.org/10.1091/mbc.E16-02-0104 Text en © 2016 Varadarajan et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Varadarajan, Ramya Ayeni, Joseph Jin, Zhigang Homola, Ellen Campbell, Shelagh D. |
| spellingShingle |
Varadarajan, Ramya Ayeni, Joseph Jin, Zhigang Homola, Ellen Campbell, Shelagh D. Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes |
| author_facet |
Varadarajan, Ramya Ayeni, Joseph Jin, Zhigang Homola, Ellen Campbell, Shelagh D. |
| author_sort |
Varadarajan, Ramya |
| title |
Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes |
| title_short |
Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes |
| title_full |
Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes |
| title_fullStr |
Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes |
| title_full_unstemmed |
Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes |
| title_sort |
myt1 inhibition of cyclin a/cdk1 is essential for fusome integrity and premeiotic centriole engagement in drosophila spermatocytes |
| description |
Drosophila Myt1 is essential for male fertility. Loss of Myt1 activity causes defective fusomes and premature centriole disengagement during premeiotic G2 phase due to lack of Myt1 inhibition of Cyclin A/Cdk1. These functions are distinct from known roles for Myt1 inhibition of Cyclin B/Cdk1 used to regulate G2/MI timing. |
| publisher |
The American Society for Cell Biology |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927279/ |
| _version_ |
1613601857723170816 |