Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. Here, we explain this paradox by showing that both drugs induce NMDA receptor-containing, AMPA receptor (AMPAR)-silent excitato...

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Bibliographic Details
Main Authors: Graziane, Nicholas M., Sun, Shichao, Wright, William J., Jang, Daniel, Liu, Zheng, Huang, Yanhua H., Nestler, Eric J., Wang, Yu Tian, Schlüter, Oliver M., Dong, Yan
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925174/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925174/

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