Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving

Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving

In rat models of drug relapse and craving, cue-induced cocaine seeking progressively increases after drug withdrawal. This ‘incubation of cocaine craving’ is partially mediated by time-dependent adaptations at glutamatergic synapses in nucleus accumbens. However, the circuit-level adaptations mediat...

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Bibliographic Details
Main Authors: Lee, Brian R., Ma, Yao-ying, Huang, Yanhua H., Wang, Xiusong, Otaka, Mami, Ishikawa, Masago, Neumann, Peter A., Graziane, Nicolas M., Brown, Travis E., Suska, Anna, Guo, Changyong, Lobo, Mary Kay, Sesack, Susan R., Wolf, Marina E., Nestler, Eric J., Shaham, Yavin, Schlüter, Oliver M., Dong, Yan
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815713/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815713/

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