Reduction of gastric cancer proliferation and invasion by miR-15a mediated suppression of Bmi-1 translation

Reduction of gastric cancer proliferation and invasion by miR-15a mediated suppression of Bmi-1 translation

B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays important roles in gastric cancer, but the epigenetic regulatory mechanism by microRNA (miRNA) and the functional significance of Bmi-1 inhibition in gastric cancer remains elusive. In this study, we systematically investigat...

Full description

Bibliographic Details
Main Authors:	Wu, Changping, Zheng, Xiao, Li, Xiaodong, Fesler, Andrew, Hu, Wenwei, Chen, Lujun, Xu, Bin, Wang, Qi, Tong, Anthony, Burke, Stephanie, Ju, Jingfang, Jiang, Jingting
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924733/

Similar Items

Identification of miR-215 mediated targets/pathways via translational immunoprecipitation expression analysis (TrIP-chip)
by: Fesler, Andrew, et al.
Published: (2015)

Prognostic Significance of miR-181b and miR-21 in Gastric Cancer Patients Treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin
by: Jiang, Jingting, et al.
Published: (2011)

miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer
by: Fesler, Andrew, et al.
Published: (2014)

IL-1β-Mediated Up-Regulation of WT1D via miR-144-3p and Their Synergistic Effect with NF-κB/COX-2/HIF-1α Pathway on Cell Proliferation in LUAD
by: Chen Wu, et al.
Published: (2018-08-01)

Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy
by: Zhai, Haiyan, et al.
Published: (2015)

miR-449 inhibits cell proliferation and is down-regulated in gastric cancer
by: Bou Kheir, Tony, et al.
Published: (2011)

miR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1
by: Zhang, Yi, et al.
Published: (2016)

A polymorphism site in the pre-miR-34a coding region reduces miR-34a expression and promotes osteosarcoma cell proliferation and migration
by: LV, HONGLIN, et al.
Published: (2014)

Prognostic significance of miR-194 in endometrial cancer
by: Zhai, Haiyan, et al.
Published: (2013)

miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level
by: Gao, Shen-meng, et al.
Published: (2011)

Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells
by: Lee, Sun Hee, et al.
Published: (2015)

IL-10Rα expression is post-transcriptionally regulated by miR-15a, miR-185, and miR-211 in melanoma
by: Venza, Isabella, et al.
Published: (2015)

Plasma miR-15b-5p, miR-338-5p, and miR-764 as Biomarkers for Hepatocellular Carcinoma
by: Chen, Yi, et al.
Published: (2015)

Prognostic Significance of miR-205 in Endometrial Cancer
by: Karaayvaz, Mihriban, et al.
Published: (2012)

miR-20b overexpression is predictive of poor prognosis in gastric cancer
by: Xue, Tong-min, et al.
Published: (2015)

Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas
by: Liang, Muh-Lii, et al.
Published: (2016)

Association of TIMP-2-418G/C and TIMP-2-303G/A with gastric cancer: a meta-analysis
by: Yang, Yan, et al.
Published: (2016)

miR-542-3p overexpression is associated with enhanced osteosarcoma cell proliferation and migration ability by targeting Van Gogh-like 2
by: LI, HUAZHUANG, et al.
Published: (2015)

Implications of Circadian Rhythm Regulation by microRNAs in Colorectal Cancer
by: Wu, Song, et al.
Published: (2016)

The expanding regulatory universe of p53 in gastrointestinal cancer
by: Fesler, Andrew, et al.
Published: (2016)

miR-200c Inhibits invasion, migration and proliferation of bladder cancer cells through down-regulation of BMI-1 and E2F3
by: Liu, Lei, et al.
Published: (2014)

Inhibition of autophagy and tumor growth in colon cancer by miR-502
by: Zhai, Haiyan, et al.
Published: (2012)

miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma
by: Ivo D’Urso, Pietro, et al.
Published: (2015)

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin
by: Huang, Nunu, et al.
Published: (2015)

Plasma microRNAs, miR-223, miR-21 and miR-218, as Novel Potential Biomarkers for Gastric Cancer Detection
by: Li, Bo-sheng, et al.
Published: (2012)

MiR-15b Targets Cyclin D1 to Regulate Proliferation and Apoptosis in Glioma Cells
by: Sun, Guan, et al.
Published: (2014)

LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141
by: Ke Liu, et al.
Published: (2017-07-01)

miR-15b induced by platelet-derived growth factor signaling is required for vascular smooth muscle cell proliferation
by: Kim, Sunghwan, et al.
Published: (2013)

miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer
by: Zhang, J, et al.
Published: (2012)

A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells
by: Dimri, Manjari, et al.
Published: (2016)

Computed tomography-guided permanent brachytherapy for locoregional recurrent gastric cancer
by: Shi, Liangrong, et al.
Published: (2012)

Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance
by: Lujun Chen, et al.
Published: (2018-09-01)

Correction to: Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance
by: Lujun Chen, et al.
Published: (2018-09-01)

The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer
by: Guo, Li-Hua, et al.
Published: (2013)

miR-221 and miR-222 Simultaneously Target RECK and Regulate Growth and Invasion of Gastric Cancer Cells
by: Liu, Wenneng, et al.
Published: (2015)

Posttranscriptional deregulation of Src due to aberrant miR34a and miR203 contributes to gastric cancer development
by: Hao, Qiang, et al.
Published: (2013)

miR-511 and miR-1297 Inhibit Human Lung Adenocarcinoma Cell Proliferation by Targeting Oncogene TRIB2
by: Zhang, Chao, et al.
Published: (2012)

miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer
by: Yan, Xin, et al.
Published: (2014)

MiR-143 and MiR-145 Regulate IGF1R to Suppress Cell Proliferation in Colorectal Cancer
by: Su, Jiaojiao, et al.
Published: (2014)

miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells
by: Guo, Shui-Long, et al.
Published: (2011)