Bone structure and function in male C57BL/6 mice: Effects of a high-fat Western-style diet with or without trace minerals

•Male mice experienced more bone loss on a high-fat Western diet than on a chow diet.•Bone loss was mitigated with a combination of calcium and trace minerals.•Bone structure and function improved in both femora and vertebrae.•Bone strontium was increased in parallel with improvement.

Bibliographic Details
Main Authors: Aslam, Muhammad Nadeem, Jepsen, Karl J., Khoury, Basma, Graf, Kristin H., Varani, James
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920365/
Description
Summary:•Male mice experienced more bone loss on a high-fat Western diet than on a chow diet.•Bone loss was mitigated with a combination of calcium and trace minerals.•Bone structure and function improved in both femora and vertebrae.•Bone strontium was increased in parallel with improvement.