Mediator and TREX-2: Emerging links between transcription initiation and mRNA export

Mediator and TREX-2: Emerging links between transcription initiation and mRNA export

Nuclear pore proteins interact dynamically with chromatin to regulate gene activities. A key question is how nucleoporin interactions mechanistically alter a gene's intranuclear position and transcriptional output. We reported recently on a direct interaction between the nuclear pore-associated...

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Main Authors: Schubert, Tobias, Köhler, Alwin
Format: Online
Language:English
Published: Taylor & Francis 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916883/
id pubmed-4916883
recordtype oai_dc
spelling pubmed-49168832016-07-06 Mediator and TREX-2: Emerging links between transcription initiation and mRNA export Schubert, Tobias Köhler, Alwin Extra Views Nuclear pore proteins interact dynamically with chromatin to regulate gene activities. A key question is how nucleoporin interactions mechanistically alter a gene's intranuclear position and transcriptional output. We reported recently on a direct interaction between the nuclear pore-associated TREX-2 complex and promoter-bound Mediator. This highlights how nuclear-pore associated adaptors gain regulatory access to the core transcription machinery. In this Extra View, we discuss an additional implication that arises from our work and the recent literature: how promoter elements may regulate mRNA metabolism beyond transcription initiation. Taylor & Francis 2016-03-30 /pmc/articles/PMC4916883/ /pubmed/27028218 http://dx.doi.org/10.1080/19491034.2016.1169352 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Schubert, Tobias
Köhler, Alwin
spellingShingle Schubert, Tobias
Köhler, Alwin
Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
author_facet Schubert, Tobias
Köhler, Alwin
author_sort Schubert, Tobias
title Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
title_short Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
title_full Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
title_fullStr Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
title_full_unstemmed Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
title_sort mediator and trex-2: emerging links between transcription initiation and mrna export
description Nuclear pore proteins interact dynamically with chromatin to regulate gene activities. A key question is how nucleoporin interactions mechanistically alter a gene's intranuclear position and transcriptional output. We reported recently on a direct interaction between the nuclear pore-associated TREX-2 complex and promoter-bound Mediator. This highlights how nuclear-pore associated adaptors gain regulatory access to the core transcription machinery. In this Extra View, we discuss an additional implication that arises from our work and the recent literature: how promoter elements may regulate mRNA metabolism beyond transcription initiation.
publisher Taylor & Francis
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916883/
_version_ 1613598146302050304

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