Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

Crosslinking of regulatory immunoreceptors (RR), such as BDCA-2 (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses production of type-I interferon (IFN)-α/β and other cytokines in response to Toll-like receptor (TLR) 7/9 ligands. This cytokine-inhibitory pathway i...

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Bibliographic Details
Main Authors: Aouar, Besma, Kovarova, Denisa, Letard, Sebastien, Font-Haro, Albert, Florentin, Jonathan, Weber, Jan, Durantel, David, Chaperot, Laurence, Plumas, Joel, Trejbalova, Katerina, Hejnar, Jiri, Nunès, Jacques A., Olive, Daniel, Dubreuil, Patrice, Hirsch, Ivan, Stranska, Ruzena
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892542/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892542/

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