A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway

A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway

The oncogenic STAT3 signaling pathway is emerging as a promising target for the treatment of multiple myeloma (MM). In the present study, we identified a novel STAT3 inhibitor SC99 in a target-based high throughput screen. SC99 inhibited JAK2-STAT3 activation but had no effects on other transcriptio...

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Bibliographic Details
Main Authors: Zhang, Zubin, Mao, Hongwu, Du, Xiaolin, Zhu, Jingyu, Xu, Yujia, Wang, Siyu, Xu, Xin, Ji, Peng, Yu, Yang, Cao, Biyin, Han, Kunkun, Hou, Tingjun, Xu, Zhuan, Kong, Yan, Jiang, Gaofeng, Tang, Xiaowen, Qiao, Chunhua, Mao, Xinliang
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891041/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891041/

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