HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

Thalidomide is used in clinical practice to treat gastrointestinal vascular malformation (GIVM), but the pathogenesis of GIVM is not clear. Hypoxia inducible factor 1 alpha (HIF-1α) and 2 alpha (HIF-2α/EPAS1) are in the same family and act as master regulators of the adaptive response to hypoxia. HI...

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Bibliographic Details
Main Authors: Feng, Nan, Chen, Haiying, Fu, Sengwang, Bian, Zhaolian, Lin, Xiaolu, Yang, Li, Gao, Yunjie, Fang, Jingyuan, Ge, Zhizheng
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888746/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888746/

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