Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling

Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling

One of the requirements for tumor development is blood supply, most often driven by hypoxia-induced angiogenesis. Hypoxia induces the stabilization of hypoxia-inducible factor-1 alpha (HIF-1α), which induces expression of an angiogenic factor, vascular endothelial growth factor (VEGF). The purpose o...

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Bibliographic Details
Main Authors: Hsu, Chia-Wen, Huang, Ruili, Khuc, Thai, Shou, David, Bullock, Joshua, Grooby, Suzanne, Griffin, Sue, Zou, Chaozhong, Little, Annette, Astley, Holly, Xia, Menghang
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884984/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884984/

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