SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

Skp1‐Cul1‐F‐box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by maintaining the Gli (Glioma‐associated oncogene homolog...

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Bibliographic Details
Main Authors: Raducu, Madalina, Fung, Ella, Serres, Sébastien, Infante, Paola, Barberis, Alessandro, Fischer, Roman, Bristow, Claire, Thézénas, Marie‐Laëtitia, Finta, Csaba, Christianson, John C, Buffa, Francesca M, Kessler, Benedikt M, Sibson, Nicola R, Di Marcotullio, Lucia, Toftgård, Rune, D'Angiolella, Vincenzo
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884786/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884786/

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