Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation

Crystal and small-angle X-ray scattering structures of full-length human SUFU alone and in complex with the conserved SYGHL motif from GLI transcription factors show major conformational changes associated with binding and reveal an intrinsically disordered region crucial for pathway activation.

Bibliographic Details
Main Authors: Cherry, Amy L., Finta, Csaba, Karlström, Mikael, Jin, Qianren, Schwend, Thomas, Astorga-Wells, Juan, Zubarev, Roman A., Del Campo, Mark, Criswell, Angela R., de Sanctis, Daniele, Jovine, Luca, Toftgård, Rune
Format: Online
Language:English
Published: International Union of Crystallography 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852661/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852661/

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