DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas

DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas

Low-grade gliomas (LGGs) account for about a third of all brain tumours in children. We conducted a detailed study of DNA methylation and gene expression to improve our understanding of the biology of pilocytic and diffuse astrocytomas. Pilocytic astrocytomas were found to have a distinctive signatu...

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Bibliographic Details
Main Authors: Jeyapalan, Jennie N., Doctor, Gabriel T., Jones, Tania A., Alberman, Samuel N., Tep, Alexander, Haria, Chirag M., Schwalbe, Edward C., Morley, Isabel C. F., Hill, Alfred A., LeCain, Magdalena, Ottaviani, Diego, Clifford, Steven C., Qaddoumi, Ibrahim, Tatevossian, Ruth G., Ellison, David W., Sheer, Denise
Format: Online
Language:English
Published: BioMed Central 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882864/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882864/

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