Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank
People with higher levels of neuroticism have an increased risk of several types of mental disorder. Higher neuroticism has also been associated, less consistently, with increased risk of various physical health outcomes. We hypothesised that these associations may, in part, be due to shared genetic...
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| Format: | Online |
| Language: | English |
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872414/ |
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pubmed-48724142016-05-26 Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank Gale, C R Hagenaars, S P Davies, G Hill, W D Liewald, D C M Cullen, B Penninx, B W Boomsma, D I Pell, J McIntosh, A M Smith, D J Deary, I J Harris, S E Original Article People with higher levels of neuroticism have an increased risk of several types of mental disorder. Higher neuroticism has also been associated, less consistently, with increased risk of various physical health outcomes. We hypothesised that these associations may, in part, be due to shared genetic influences. We tested for pleiotropy between neuroticism and 17 mental and physical diseases or health traits using linkage disequilibrium regression and polygenic profile scoring. Genetic correlations were derived between neuroticism scores in 108 038 people in the UK Biobank and health-related measures from 14 large genome-wide association studies (GWASs). Summary information for the 17 GWASs was used to create polygenic risk scores for the health-related measures in the UK Biobank participants. Associations between the health-related polygenic scores and neuroticism were examined using regression, adjusting for age, sex, genotyping batch, genotyping array, assessment centre and population stratification. Genetic correlations were identified between neuroticism and anorexia nervosa (rg=0.17), major depressive disorder (rg=0.66) and schizophrenia (rg=0.21). Polygenic risk for several health-related measures were associated with neuroticism, in a positive direction in the case of bipolar disorder, borderline personality, major depressive disorder, negative affect, neuroticism (Genetics of Personality Consortium), schizophrenia, coronary artery disease, and smoking (β between 0.009–0.043), and in a negative direction in the case of body mass index (β=−0.0095). A high level of pleiotropy exists between neuroticism and some measures of mental and physical health, particularly major depressive disorder and schizophrenia. Nature Publishing Group 2016-04 2016-04-26 /pmc/articles/PMC4872414/ /pubmed/27115122 http://dx.doi.org/10.1038/tp.2016.56 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gale, C R Hagenaars, S P Davies, G Hill, W D Liewald, D C M Cullen, B Penninx, B W Boomsma, D I Pell, J McIntosh, A M Smith, D J Deary, I J Harris, S E |
| spellingShingle |
Gale, C R Hagenaars, S P Davies, G Hill, W D Liewald, D C M Cullen, B Penninx, B W Boomsma, D I Pell, J McIntosh, A M Smith, D J Deary, I J Harris, S E Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank |
| author_facet |
Gale, C R Hagenaars, S P Davies, G Hill, W D Liewald, D C M Cullen, B Penninx, B W Boomsma, D I Pell, J McIntosh, A M Smith, D J Deary, I J Harris, S E |
| author_sort |
Gale, C R |
| title |
Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank |
| title_short |
Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank |
| title_full |
Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank |
| title_fullStr |
Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank |
| title_full_unstemmed |
Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank |
| title_sort |
pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in uk biobank |
| description |
People with higher levels of neuroticism have an increased risk of several types of mental disorder. Higher neuroticism has also been associated, less consistently, with increased risk of various physical health outcomes. We hypothesised that these associations may, in part, be due to shared genetic influences. We tested for pleiotropy between neuroticism and 17 mental and physical diseases or health traits using linkage disequilibrium regression and polygenic profile scoring. Genetic correlations were derived between neuroticism scores in 108 038 people in the UK Biobank and health-related measures from 14 large genome-wide association studies (GWASs). Summary information for the 17 GWASs was used to create polygenic risk scores for the health-related measures in the UK Biobank participants. Associations between the health-related polygenic scores and neuroticism were examined using regression, adjusting for age, sex, genotyping batch, genotyping array, assessment centre and population stratification. Genetic correlations were identified between neuroticism and anorexia nervosa (rg=0.17), major depressive disorder (rg=0.66) and schizophrenia (rg=0.21). Polygenic risk for several health-related measures were associated with neuroticism, in a positive direction in the case of bipolar disorder, borderline personality, major depressive disorder, negative affect, neuroticism (Genetics of Personality Consortium), schizophrenia, coronary artery disease, and smoking (β between 0.009–0.043), and in a negative direction in the case of body mass index (β=−0.0095). A high level of pleiotropy exists between neuroticism and some measures of mental and physical health, particularly major depressive disorder and schizophrenia. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872414/ |
| _version_ |
1613581314051538944 |