Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo

Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo

In cultured cancer cells the E3 ubiquitin ligase Rad18 activates Trans-Lesion Synthesis (TLS) and the Fanconi Anemia (FA) pathway. However, physiological roles of Rad18 in DNA damage tolerance and carcinogenesis are unknown and were investigated here. Primary hematopoietic stem and progenitor cells...

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Bibliographic Details
Main Authors: Yang, Yang, Poe, Jonathan C., Yang, Lisong, Fedoriw, Andrew, Desai, Siddhi, Magnuson, Terry, Li, Zhiguo, Fedoriw, Yuri, Araki, Kimi, Gao, Yanzhe, Tateishi, Satoshi, Sarantopoulos, Stefanie, Vaziri, Cyrus
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872084/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872084/

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