A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, rate-limiting step. Genetic lo...

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Bibliographic Details
Main Authors: Pacold, Michael E., Brimacombe, Kyle R., Chan, Sze Ham, Rohde, Jason M., Lewis, Caroline A., Swier, Lotteke J.Y.M., Possemato, Richard, Chen, Walter W., Sullivan, Lucas B., Fiske, Brian P., Cho, Sung Won, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D., Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M., Luengo, Alba, Wang, Amy Q., Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D., Vander Heiden, Matthew G., Shen, Min, Gray, Nathanael S., Boxer, Matthew B., Sabatini, David M.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871733/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871733/

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