A unifying model for mTORC1-mediated regulation of mRNA translation

by Thoreen, Carson C., Chantranupong, Lynne, Keys, Heather R., Wang, Tim, Gray, Nathanael S., Sabatini, David M.
Published 2012

BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner

by Lau, Ken S., Zhang, Tinghu, Kendall, Krystle R., Lauffenburger, Douglas, Gray, Nathanael S., Haigis, Kevin M.
Published 2012

Chaperones as thermodynamic sensors of drug–target interactions reveal kinase inhibitor specificities in living cells

by Taipale, Mikko, Krykbaeva, Irina, Whitesell, Luke, Santagata, Sandro, Zhang, Jianming, Liu, Qingsong, Gray, Nathanael S., Lindquist, Susan
Published 2013

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

by Zhao, Zheng, Wu, Hong, Wang, Li, Liu, Yi, Knapp, Stefan, Liu, Qingsong, Gray, Nathanael S.
Published 2014

Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors

by Canning, Peter, Tan, Li, Chu, Kiki, Lee, Sam W., Gray, Nathanael S., Bullock, Alex N.
Published 2014

Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity

by Williams, Charles A.C., Fernandez-Alonso, Rosalia, Wang, Jinhua, Toth, Rachel, Gray, Nathanael S., Findlay, Greg M.
Published 2016

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

by Chaikuad, Apirat, Tacconi, Eliana, Zimmer, Jutta, Liang, Yanke, Gray, Nathanael S., Tarsounas, Madalena, Knapp, Stefan
Published 2014

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

by Malik, Nazma, Vollmer, Stefan, Nanda, Sambit Kumar, Lopez-Pelaez, Marta, Prescott, Alan, Gray, Nathanael, Cohen, Philip
Published 2015

Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

by Fallahi-Sichani, Mohammad, Moerke, Nathan J, Niepel, Mario, Zhang, Tinghu, Gray, Nathanael S, Sorger, Peter K
Published 2015

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1

by Deng, Xianming, Yang, Qingkai, Kwiatkowski, Nicholas, Sim, Taebo, McDermott, Ultan, Settleman, Jeffrey E., Lee, Jiing-Dwan, Gray, Nathanael S.
Published 2011

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

by Saenz, Jose B., Sun, William J., Chang, Jae Won, Li, Jinmei, Bursulaya, Badry, Gray, Nathanael S., Haslam, David B.
Published 2009

Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer

by Terai, Hideki, Tan, Li, Beauchamp, Ellen M., Hatcher, John M., Liu, Qingsong, Meyerson, Matthew, Gray, Nathanael S., Hammerman, Peter S.
Published 2015

Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells

by Ho, Catherine M. K., Donovan-Banfield, I’ah Z., Tan, Li, Zhang, Tinghu, Gray, Nathanael S., Strang, Blair L.
Published 2016

Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2

by Deng, Xianming, Dzamko, Nicolas, Prescott, Alan, Davies, Paul, Liu, Qingsong, Yang, Qingkai, Lee, Jiing-Dwan, Patricelli, Matthew P., Nomanbhoy, Tyzoon K., Alessi, Dario R., Gray, Nathanael S.
Published 2011

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors

by Deng, Xianming, Wang, Jinhua, Zhang, Jianming, Sim, Taebo, Kim, Nam Doo, Sasaki, Takaaki, Luther, William, George, Rani E., Jänne, Pasi A., Gray, Nathanael S.
Published 2011

Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer

by Dutt, Amit, Ramos, Alex H., Hammerman, Peter S., Mermel, Craig, Cho, Jeonghee, Sharifnia, Tanaz, Chande, Ajit, Tanaka, Kumiko Elisa, Stransky, Nicolas, Greulich, Heidi, Gray, Nathanael S., Meyerson, Matthew
Published 2011

Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation

by McMillin, Douglas W., Delmore, Jake, Negri, Joseph, Ooi, Melissa, Klippel, Steffen, Miduturu, Chandrasekhar V., Gray, Nathanael S., Richardson, Paul G., Anderson, Kenneth C., Kung, Andrew L., Mitsiades, Constantine S.
Published 2011

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

by Dzamko, Nicolas, Inesta-Vaquera, Francisco, Zhang, Jiazhen, Xie, Chengsong, Cai, Huaibin, Arthur, Simon, Tan, Li, Choi, Hwanguen, Gray, Nathanael, Cohen, Philip, Pedrioli, Patrick, Clark, Kristopher, Alessi, Dario R.
Published 2012

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

by Elkins, Jonathan M., Wang, Jing, Deng, Xianming, Pattison, Michael J., Arthur, J. Simon C., Erazo, Tatiana, Gomez, Nestor, Lizcano, Jose M., Gray, Nathanael S., Knapp, Stefan
Published 2013

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

by Banerjee, Sourav, Buhrlage, Sara J., Huang, Hai-Tsang, Deng, Xianming, Zhou, Wenjun, Wang, Jinhua, Traynor, Ryan, Prescott, Alan R., Alessi, Dario R., Gray, Nathanael S.
Published 2013