LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor†

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor†

The bromodomain‐containing proteins BRD9 and BRD7 are part of the human SWI/SNF chromatin‐remodeling complexes BAF and PBAF. To date, no selective inhibitor for BRD7/9 has been reported despite its potential value as a biological tool or as a lead for future therapeutics. The quinolone‐fused lactam...

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Bibliographic Details
Main Authors: Clark, Peter G. K., Vieira, Lucas C. C., Tallant, Cynthia, Fedorov, Oleg, Singleton, Dean C., Rogers, Catherine M., Monteiro, Octovia P., Bennett, James M., Baronio, Roberta, Müller, Susanne, Daniels, Danette L., Méndez, Jacqui, Knapp, Stefan, Brennan, Paul E., Dixon, Darren J.
Format: Online
Language:English
Published: WILEY‐VCH Verlag 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871321/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871321/

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