Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis

Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis

Therapeutic success of VEGF-based anti-angiogenic tumor therapy is limited due to resistance. Thus, new strategies for anti-angiogenic cancer therapy based on novel targets are urgently required. Our previous in vitro work suggested that small molecule Cdk5 inhibitors affect angiogenic processes suc...

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Bibliographic Details
Main Authors: Merk, Henriette, Zhang, Siwei, Lehr, Thorsten, Müller, Christoph, Ulrich, Melanie, Bibb, James A., Adams, Ralf H., Bracher, Franz, Zahler, Stefan, Vollmar, Angelika M., Liebl, Johanna
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868742/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868742/

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