Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling

Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling

PEL is a B-cell non-Hodgkin lymphoma, occurring predominantly as a lymphomatous effusion in body cavities, characterized by aggressive clinical course, with no standard therapy. Based on previous reports that PEL cells display a Warburg phenotype, we hypothesized that the highly hypoxic environment...

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Bibliographic Details
Main Authors: Mediani, Laura, Gibellini, Federica, Bertacchini, Jessika, Frasson, Chiara, Bosco, Raffaella, Accordi, Benedetta, Basso, Giuseppe, Bonora, Massimo, Calabrò, Maria Luisa, Mattiolo, Adriana, Sgarbi, Gianluca, Baracca, Alessandra, Pinton, Paolo, Riva, Giovanni, Rampazzo, Enrico, Petrizza, Luca, Prodi, Luca, Milani, Daniela, Luppi, Mario, Potenza, Leonardo, De Pol, Anto, Cocco, Lucio, Capitani, Silvano, Marmiroli, Sandra
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868703/

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