STIM1-dependent Ca2+ microdomains are required for myofilament remodeling and signaling in the heart

In non-excitable cells stromal interaction molecule 1 (STIM1) is a key element in the generation of Ca2+ signals that lead to gene expression, migration and cell proliferation. A growing body of literature suggests that STIM1 plays a key role in the development of pathological cardiac hypertrophy. H...

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Bibliographic Details
Main Authors: Parks, Cory, Alam, Mohammad Afaque, Sullivan, Ryan, Mancarella, Salvatore
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858716/