Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a...

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Main Authors: Smith, J. Gustav, Felix, Janine F., Morrison, Alanna C., Kalogeropoulos, Andreas, Trompet, Stella, Wilk, Jemma B., Gidlöf, Olof, Wang, Xinchen, Morley, Michael, Mendelson, Michael, Joehanes, Roby, Ligthart, Symen, Shan, Xiaoyin, Bis, Joshua C., Wang, Ying A., Sjögren, Marketa, Ngwa, Julius, Brandimarto, Jeffrey, Stott, David J., Aguilar, David, Rice, Kenneth M., Sesso, Howard D., Demissie, Serkalem, Buckley, Brendan M., Taylor, Kent D., Ford, Ian, Yao, Chen, Liu, Chunyu, Sotoodehnia, Nona, van der Harst, Pim, Stricker, Bruno H. Ch., Kritchevsky, Stephen B., Liu, Yongmei, Gaziano, J. Michael, Hofman, Albert, Moravec, Christine S., Uitterlinden, André G., Kellis, Manolis, van Meurs, Joyce B., Margulies, Kenneth B., Dehghan, Abbas, Levy, Daniel, Olde, Björn, Psaty, Bruce M., Cupples, L. Adrienne, Jukema, J. Wouter, Djousse, Luc, Franco, Oscar H., Boerwinkle, Eric, Boyer, Laurie A., Newton-Cheh, Christopher, Butler, Javed, Vasan, Ramachandran S., Cappola, Thomas P., Smith, Nicholas L.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858216/

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