Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes

Infection by Group A Streptococcus pyogenes (GAS) is a leading cause of severe invasive disease in humans, including streptococcal toxic shock syndrome and necrotizing fasciitis. GAS infections lead to nearly 163,000 annual deaths worldwide. Hypervirulent strains of S. pyogenes have evolved a pletho...

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Bibliographic Details
Main Authors: Moon, Andrea F., Krahn, Juno M., Lu, Xun, Cuneo, Matthew J., Pedersen, Lars C.
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856990/