Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)

Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)

Efficient processing of target antigens by the ubiquitin-proteasome-system (UPS) is essential for treatment of cancers by T cell therapies. However, immune escape due to altered expression of IFN-γ-inducible components of the antigen presentation machinery and consequent inefficient processing of HL...

Full description

Bibliographic Details
Main Authors: Ebstein, Frédéric, Keller, Martin, Paschen, Annette, Walden, Peter, Seeger, Michael, Bürger, Elke, Krüger, Elke, Schadendorf, Dirk, Kloetzel, Peter-M., Seifert, Ulrike
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855237/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855237/

Similar Items