B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

Jackson et al. propose a role for B cell–intrinsic IFN-γ receptor signaling in spontaneous germinal center activation and autoantibody production.

Bibliographic Details
Main Authors:	Jackson, Shaun W., Jacobs, Holly M., Arkatkar, Tanvi, Dam, Elizabeth M., Scharping, Nicole E., Kolhatkar, Nikita S., Hou, Baidong, Buckner, Jane H., Rawlings, David J.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854732/

Similar Items

IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity
by: Domeier, Phillip P., et al.
Published: (2016)

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
by: Becker-Herman, Shirly, et al.
Published: (2011)

LIGHT/IFN‐γ triggers β cells apoptosis via NF‐κB/Bcl2‐dependent mitochondrial pathway
by: Zheng, Quan‐You, et al.
Published: (2016)

IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
by: Carpio, Victor H., et al.
Published: (2015)

Paradoxical roles of IFN-γ in models of Th1-mediated autoimmunity
by: Rosloniec, Edward F, et al.
Published: (2002)

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability
by: Hindinger, Claudia, et al.
Published: (2012)

Artesunate Abolishes Germinal Center B Cells and Inhibits Autoimmune Arthritis
by: Hou, Lifei, et al.
Published: (2014)

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells
by: Raetz, Megan, et al.
Published: (2012)

Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
by: Lee, Chang Hoon, et al.
Published: (2006)

Cytometric evaluation of intracellular IFN-γ and IL-4 levels in thyroid follicular cells from patients with autoimmune thyroid diseases
by: Bossowski, Artur, et al.
Published: (2011)

Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
by: Fukuda, Tetsuya, et al.
Published: (1997)

Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas
by: Goteri, Gaia, et al.
Published: (2011)

Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
by: Giltiay, Natalia V., et al.
Published: (2013)

Identification of IFN-γ-producing innate B cells
by: Bao, Yan, et al.
Published: (2014)

B cell–intrinsic TLR signals amplify but are not required for humoral immunity
by: Meyer-Bahlburg, Almut, et al.
Published: (2007)

Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells
by: Liu, Hui, et al.
Published: (2006)

Correction: IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
by: Carpio, Victor H., et al.
Published: (2016)

STAT1-Mediated Down-Regulation of Bcl-2 Expression Is Involved in IFN-γ/TNF-α–Induced Apoptosis in NIT-1 Cells
by: Cao, Zhao-hui, et al.
Published: (2015)

Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
by: Chung, Yeonseok, et al.
Published: (2011)

EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
by: Ryan, Russell J. H., et al.
Published: (2011)

BCL6 Controls the Expression of the B7-1/CD80 Costimulatory Receptor in Germinal Center B Cells
by: Niu, Huifeng, et al.
Published: (2003)

IFN-γ Mediates the Rejection of Haematopoietic Stem Cells in IFN-γR1-Deficient Hosts
by: Rottman, Martin, et al.
Published: (2008)

IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure
by: Li, Zhong-Yin, et al.
Published: (2015)

Physiological evidence for diversification of IFNα- and IFNβ-mediated response programs in different autoimmune diseases
by: de Jong, Tamarah D., et al.
Published: (2016)

Interferon γ (IFN-γ) Is Necessary for the Genesis of Acetylcholine Receptor–induced Clinical Experimental Autoimmune Myasthenia gravis in Mice
by: Balasa, Balaji, et al.
Published: (1997)

Germinal Center B Cell Depletion Diminishes CD4+ Follicular T Helper Cells in Autoimmune Mice
by: Yusuf, Isharat, et al.
Published: (2014)

Interferon (IFNγ) induces cell cycle arrest in RCC cell lines
by: Tate, David J, et al.
Published: (2013)

Innate IFN-γ-Producing Cells in the Spleen of Mice Early after Listeria monocytogenes Infection: Importance of Microenvironment of the Cells Involved in the Production of Innate IFN-γ
by: Kubota, Koichi, et al.
Published: (2011)

Zeaxanthin Induces Apoptosis in Human Uveal Melanoma Cells through Bcl-2 Family Proteins and Intrinsic Apoptosis Pathway
by: Bi, Ming-Chao, et al.
Published: (2013)

IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity
by: Kocur, Magdalena, et al.
Published: (2015)

Intrinsic properties of germinal center‐derived B cells promote their enhanced class switching to IgE
by: Ramadani, F., et al.
Published: (2015)

Germinal Centers without T Cells
by: de Vinuesa, Carola García, et al.
Published: (2000)

bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells
by: Smith, Kenneth G.C., et al.
Published: (2000)

Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses
by: Li, Yanchuan, et al.
Published: (2016)

Cell-Specific Type I IFN Signatures in Autoimmunity and Viral Infection: What Makes the Difference?
by: Kyogoku, Chieko, et al.
Published: (2013)

Dynamics of Intraocular IFN-γ, IL-17 and IL-10-Producing Cell Populations during Relapsing and Monophasic Rat Experimental Autoimmune Uveitis
by: Kaufmann, Ulrike, et al.
Published: (2012)

Cholinergic Stimulation Prevents the Development of Autoimmune Diabetes: Evidence for the Modulation of Th17 Effector Cells via an IFNγ-Dependent Mechanism
by: George, Junu A., et al.
Published: (2016)

Lithium Controls Central Nervous System Autoimmunity through Modulation of IFN-γ Signaling
by: Rowse, Amber L., et al.
Published: (2012)

Sinomenine reduces iNOS expression via inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats
by: Gu, Bingjie, et al.
Published: (2012)

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis
by: Savarin, Carine, et al.
Published: (2015)