EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas

EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas

Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and enhanced tri-methylation of histone H3 at lysine 27, a repressive chromatin modification. As an initial step toward screening patients for cancer...

Full description

Bibliographic Details
Main Authors: Ryan, Russell J. H., Nitta, Mai, Borger, Darrell, Zukerberg, Lawrence R., Ferry, Judith A., Harris, Nancy Lee, Iafrate, A. John, Bernstein, Bradley E., Sohani, Aliyah R., Le, Long Phi
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237460/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237460/

Similar Items