Proline-based Phosphoramidite Reagents for the Reductive Ligation of S-Nitrosothiols

S-Nitrosothiols have many biological implications but are rarely used in organic synthesis. In this work we report the development of proline-based phosphoramidite substrates that can effectively convert S-nitrosothiols to proline-based sulfenamides through a reductive ligation process. A unique pro...

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Bibliographic Details
Main Authors: Park, Chung-Min, Biggs, Tyler D., Xian, Ming
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848125/