Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex

Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex

Chromatin DNA must be read out for various cellular functions, and copied for the next cell division. These processes are targets of many anticancer agents. Platinum-based drugs, such as cisplatin, have been used extensively in cancer chemotherapy. The drug–DNA interaction causes DNA crosslinks and...

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Bibliographic Details
Main Authors: Imai, Ryosuke, Komeda, Seiji, Shimura, Mari, Tamura, Sachiko, Matsuyama, Satoshi, Nishimura, Kohei, Rogge, Ryan, Matsunaga, Akihiro, Hiratani, Ichiro, Takata, Hideaki, Uemura, Masako, Iida, Yutaka, Yoshikawa, Yuko, Hansen, Jeffrey C., Yamauchi, Kazuto, Kanemaki, Masato T., Maeshima, Kazuhiro
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837362/

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