Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re‐sensitization by JNK inhibition

Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re‐sensitization by JNK inhibition

Glucocorticoid (GC) resistance is a continuing clinical problem in childhood acute lymphoblastic leukaemia (ALL) but the underlying mechanisms remain unclear. A proteomic approach was used to compare profiles of the B‐lineage ALL GC‐sensitive cell line, PreB 697, and its GC‐resistant sub‐line, R3F9,...

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Bibliographic Details
Main Authors: Nicholson, Lindsay, Evans, Caroline A., Matheson, Elizabeth, Minto, Lynne, Keilty, Christopher, Sanichar, Maryna, Case, Marian, Schwab, Claire, Williamson, Daniel, Rainer, Johannes, Harrison, Christine J., Kofler, Reinhard, Hall, Andrew G., Redfern, Christopher P. F., Whetton, Anthony D., Irving, Julie A. E.
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833193/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833193/

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