Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells

Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells

MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling pathways. With MALT1A and MALT1B two conserved splice variants exist and we demonstrate here that MALT1 alternative splicing supports optimal T-cell activation. Inclusion of exon7 in MALT1A facilitates the recruitment...

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Bibliographic Details
Main Authors: Meininger, Isabel, Griesbach, Richard A., Hu, Desheng, Gehring, Torben, Seeholzer, Thomas, Bertossi, Arianna, Kranich, Jan, Oeckinghaus, Andrea, Eitelhuber, Andrea C., Greczmiel, Ute, Gewies, Andreas, Schmidt-Supprian, Marc, Ruland, Jürgen, Brocker, Thomas, Heissmeyer, Vigo, Heyd, Florian, Krappmann, Daniel
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832065/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832065/

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