| Summary: | In 73 gDNA samples from Babesia gibsoni-infected dogs, the M121I variant
population was measured by using allele-specific real-time PCR. Although the mechanism of
atovaquone against B. gibsoni has not been clearly identified, it is
reported that the mitochondria cytochrome b gene of the
atovaquone-resistant B. gibsoni had a single-nucleotide substitution at
nt363 (G to T), which resulted in the substitution of methionine with isoleucine (M121I).
In this study, 3/73 samples showed over 5% M121I variant population. Although the M121I
variant population is a low percentage, it runs the risk of spreading drug-resistant
parasites. It is important to prevent the spread of drug-resistance, so we need to gather
information about this at regular intervals.
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