DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy

DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy

Aneuploidy, the unbalanced number of chromosomes in a cell, is considered a prevalent form of genetic instability and is largely acknowledged as a condition implicated in tumorigenesis. Epigenetic alterations like DNA hypomethylation have been correlated with cancer initiation/progression. Furthermo...

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Main Authors: Costa, Giuseppe, Barra, Viviana, Lentini, Laura, Cilluffo, Danilo, Di Leonardo, Aldo
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826165/
id pubmed-4826165
recordtype oai_dc
spelling pubmed-48261652016-05-09 DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy Costa, Giuseppe Barra, Viviana Lentini, Laura Cilluffo, Danilo Di Leonardo, Aldo Research Paper: Chromosome Aneuploidy, the unbalanced number of chromosomes in a cell, is considered a prevalent form of genetic instability and is largely acknowledged as a condition implicated in tumorigenesis. Epigenetic alterations like DNA hypomethylation have been correlated with cancer initiation/progression. Furthermore, a growing body of evidence suggests the involvement of epigenome-wide disruption as a cause of global DNA hypomethylation in aneuploidy generation. Impact Journals LLC 2016-01-12 /pmc/articles/PMC4826165/ /pubmed/26771138 http://dx.doi.org/10.18632/oncotarget.6897 Text en Copyright: © 2016 Costa et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Costa, Giuseppe
Barra, Viviana
Lentini, Laura
Cilluffo, Danilo
Di Leonardo, Aldo
spellingShingle Costa, Giuseppe
Barra, Viviana
Lentini, Laura
Cilluffo, Danilo
Di Leonardo, Aldo
DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
author_facet Costa, Giuseppe
Barra, Viviana
Lentini, Laura
Cilluffo, Danilo
Di Leonardo, Aldo
author_sort Costa, Giuseppe
title DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
title_short DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
title_full DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
title_fullStr DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
title_full_unstemmed DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
title_sort dna demethylation caused by 5-aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
description Aneuploidy, the unbalanced number of chromosomes in a cell, is considered a prevalent form of genetic instability and is largely acknowledged as a condition implicated in tumorigenesis. Epigenetic alterations like DNA hypomethylation have been correlated with cancer initiation/progression. Furthermore, a growing body of evidence suggests the involvement of epigenome-wide disruption as a cause of global DNA hypomethylation in aneuploidy generation.
publisher Impact Journals LLC
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826165/
_version_ 1613564243378962432

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