Long term Glycemic Control Using Polymer Encapsulated, Human Stem-Cell Derived β-cells in Immune Competent mice

Long term Glycemic Control Using Polymer Encapsulated, Human Stem-Cell Derived β-cells in Immune Competent mice

The transplantation of glucose-responsive, insulin-producing cells offers the potential for restoring glycemic control in diabetic patients1. Pancreas transplantation and the infusion of cadaveric islets are currently implemented clinically2, but are limited by the adverse effects of lifetime immuno...

Full description

Bibliographic Details
Main Authors:	Vegas, Arturo J., Veiseh, Omid, Gürtler, Mads, Millman, Jeffrey R., Pagliuca, Felicia W., Bader, Andrew R., Doloff, Joshua C., Li, Jie, Chen, Michael, Olejnik, Karsten, Tam, Hok Hei, Jhunjhunwala, Siddharth, Langan, Erin, Aresta-Dasilva, Stephanie, Gandham, Srujan, McGarrigle, James, Bochenek, Matthew A., Hollister-Lock, Jennifer, Oberholzer, Jose, Greiner, Dale L., Weir, Gordon C., Melton, Douglas A., Langer, Robert, Anderson, Daniel G.
Format:	Online
Language:	English
Published:	2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825868/

Similar Items

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
by: Veiseh, Omid, et al.
Published: (2015)

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
by: Vegas, Arturo J, et al.
Published: (2016)

Neutrophil Responses to Sterile Implant Materials
by: Jhunjhunwala, Siddharth, et al.
Published: (2015)

Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes
by: Millman, Jeffrey R., et al.
Published: (2016)

Generation of stem cell-derived β-cells from patients with type 1 diabetes
by: Millman, Jeffrey R., et al.
Published: (2016)

Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis
by: Gandham, Srujan Kumar, et al.
Published: (2015)

A comparison of sexual behaviour and attitudes of healthy adolescents in a Danish high school in 1982, 1996, and 2001
by: Kangas, Ida, et al.
Published: (2004)

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells
by: Sullivan, Brooke A., et al.
Published: (2015)

Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate
by: Gomez, Danielle L., et al.
Published: (2015)

Regulation of Kir Channels by Intracellular pH and Extracellular K+ : Mechanisms of Coupling
by: Dahlmann, Anke, et al.
Published: (2004)

Lower serum oestrogen concentrations associated with faster intestinal transit.
by: Lewis, S. J., et al.
Published: (1997)

An imputation/copula-based stochastic individual tree growth model for mixed species Acadian forests: a case study using the Nova Scotia permanent sample plot network
by: John A. Kershaw, et al.
Published: (2017-09-01)

Effect of rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle
by: Eghtesad, Saman, et al.
Published: (2012)

The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice
by: Molven, Anders, et al.
Published: (2016)

Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6
by: Feo, Maria Luisa, et al.
Published: (2012)

A 3,4-trans-Fused Cyclic Protecting Group Facilitates α-Selective Catalytic Synthesis of 2-Deoxyglycosides**
by: Balmond, Edward I, et al.
Published: (2014)

Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA
by: Aguayo-Mazzucato, Cristina, et al.
Published: (2013)

PDX1 in Ducts Is Not Required for Postnatal Formation of β-Cells but Is Necessary for Their Subsequent Maturation
by: Guo, Lili, et al.
Published: (2013)

Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes
by: King, Aileen J. F., et al.
Published: (2013)

Monitoring and measuring intangibles using value maps: some examples
by: Shital, Jhunjhunwala
Published: (2009)

Intertwining CSR with strategy – the way ahead
by: Shital, Jhunjhunwala
Published: (2014)

Computational modeling of airway instability and collapse in tracheomalacia
by: Scott J. Hollister, et al.
Published: (2017-04-01)

Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts
by: Doloff, Joshua C, et al.
Published: (2015)

Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity
by: Whitehead, Kathryn A., et al.
Published: (2014)

Results of uncemented distal locked prosthesis in revision hip arthroplasty with proximal femoral bone loss: A retrospective study
by: Agarwala, Sanjay, et al.
Published: (2013)

A simple tool to improve pluripotent stem cell differentiation
by: Chetty, Sundari, et al.
Published: (2013)

Bringing information literacy to career services
by: Christopher, Hollister
Published: (2005)

Beyond the interaction membrane: Laud Humphreys’ tearoom tradeoff
by: John, Hollister
Published: (2004)

The Non-motor Features of Essential Tremor: A Primary Disease Feature or Just a Secondary Phenomenon?
by: Jhunjhunwala, Ketan, et al.
Published: (2014)

Effects of Co-current and Cross Flows on Circular Enhanced Gravity Plate Separator Efficiencies
by: Ngu, Lock Hei, et al.
Published: (2014)

Combining Residual Insecticide Spraying Campaigns with Targeted Detection and Specific Chemotherapy for Trypanosoma cruzi Infection in Children
by: Gürtler, Ricardo E.
Published: (2007)

Forecasting performance of time series models on electricity spot markets: a quasi-meta-analysis
by: Marc, Gürtler, et al.
Published: (2018)

Elevated Tumor Expression of PAI-1 and SNAI2 in Obese Esophageal Adenocarcinoma Patients and Impact on Prognosis
by: Allott, Emma H, et al.
Published: (2012)

A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers
by: Guinan, Emer M, et al.
Published: (2013)

Corrigendum: The characterization of an intestine-like genomic signature maintained during Barrett’s-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival
by: Duggan, Shane P., et al.
Published: (2016)

The characterization of an intestine-like genomic signature maintained during Barrett’s-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival
by: Duggan, Shane P., et al.
Published: (2016)

Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst
by: Medina, Sandra, et al.
Published: (2016)

Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2
by: Doloff, Joshua C, et al.
Published: (2014)

School Choice, Student Performance, and Teacher and School Characteristics : The Chilean Case
by: Vegas, Emiliana
Published: (2013)

Incentives to Improve Teaching : Lessons from Latin America
by: Vegas, Emiliana
Published: (2012)