Computing the origin and evolution of the ribosome from its structure — Uncovering processes of macromolecular accretion benefiting synthetic biology
Accretion occurs pervasively in nature at widely different timeframes. The process also manifests in the evolution of macromolecules. Here we review recent computational and structural biology studies of evolutionary accretion that make use of the ideographic (historical, retrodictive) and nomotheti...
Main Authors: | Caetano-Anollés, Gustavo, Caetano-Anollés, Derek |
---|---|
Format: | Online |
Language: | English |
Published: |
Research Network of Computational and Structural Biotechnology
2015
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823900/ |
Similar Items
-
Ribosomal accretion, apriorism and the phylogenetic method: a response to Petrov and Williams
by: Caetano-Anollés, Derek, et al.
Published: (2015) -
Structural Phylogenomics Retrodicts the Origin of the Genetic Code and Uncovers the Evolutionary Impact of Protein Flexibility
by: Caetano-Anollés, Gustavo, et al.
Published: (2013) -
Piecemeal Buildup of the Genetic Code, Ribosomes, and Genomes from Primordial tRNA Building Blocks
by: Caetano-Anollés, Derek, et al.
Published: (2016) -
Ribosomal History Reveals Origins of Modern Protein Synthesis
by: Harish, Ajith, et al.
Published: (2012) -
Ancestral Insertions and Expansions of rRNA do not Support an Origin of the Ribosome in Its Peptidyl Transferase Center
by: Caetano-Anollés, Gustavo
Published: (2015)