Evolutionary Optimization of Protein Folding

Nature has shaped the make up of proteins since their appearance, 3.8 billion years ago. However, the fundamental drivers of structural change responsible for the extraordinary diversity of proteins have yet to be elucidated. Here we explore if protein evolution affects folding speed. We estimated f...

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Bibliographic Details
Main Authors: Debès, Cédric, Wang, Minglei, Caetano-Anollés, Gustavo, Gräter, Frauke
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547816/